| 1 | 5-MTHF Calcium Salt
CAS 151533-22-1 | Calcium salt of L-5-methyltetrahydrofolate, commonly supplied as a powder for nutraceutical and pharmaceutical use. | Capsules, tablets, sachets, prenatal formulas, multivitamin products, and dietary supplements. | Widely recognized commercial form with established use in finished-product formulations. | Confirm L-isomer identity, assay basis, calcium content, water content, residual solvents, microbiological limits, and stability data. | Light-protective, moisture-barrier packaging; nitrogen flushing may be used where supported by the stability program. | Buyers seeking a broadly used, scalable ingredient for solid-dose products. |
| 2 | 5-MTHF Glucosamine Salt
CAS 118197-16-7 | Glucosamine salt of L-5-methyltetrahydrofolate, supplied as an active folate ingredient. | Premium dietary supplements, prenatal products, medical nutrition, and specialty formulations. | Provides an alternative salt system when the formulation avoids added calcium or requires a different excipient profile. | Verify salt stoichiometry, glucosamine source, allergen statement, assay conversion, identity testing, and applicable regulatory acceptance. | Store tightly closed, protected from light and humidity; use low-moisture handling during blending. | Buyers requiring a non-calcium salt and a clearly documented raw-material specification. |
| 3 | Crystalline 5-MTHF | Highly ordered crystalline material supplied as a controlled solid form, usually with defined particle and purity specifications. | Research, pharmaceutical development, premium supplements, and applications requiring reproducible physical properties. | Potentially improved batch-to-batch consistency in identification, flow, and solid-state characterization. | Request XRPD or equivalent solid-state data, particle-size distribution, polymorph information, assay, and stability under intended storage. | Use sealed, light-resistant containers with desiccant or moisture-control measures where justified. | Technical buyers prioritizing solid-state control and analytical reproducibility. |
| 4 | Amorphous 5-MTHF | Non-crystalline or partially amorphous material with a less ordered solid-state structure. | Specialty formulations where dissolution or dispersion performance is important. | May offer favorable dissolution characteristics, but physical stability can be more sensitive to moisture and temperature. | Confirm amorphous content, glass-transition behavior, moisture uptake, recrystallization risk, and real-time stability data. | Requires strict humidity control and packaging designed to limit moisture ingress. | Formulators prepared to manage solid-state and humidity-related risks. |
| 5 | Micronized 5-MTHF | 5-MTHF processed to a reduced particle size to improve dispersion and blend uniformity. | Low-dose tablets, hard capsules, direct-compression blends, and premixes. | Improved distribution of a low-dose active ingredient within a larger powder blend. | Check particle-size distribution, flowability, electrostatic behavior, dust control, assay uniformity, and blend-validation requirements. | Use sealed liners and controlled dispensing; avoid excessive mechanical stress that may increase dust. | Buyers manufacturing low-dose products that require reliable content uniformity. |
| 6 | Granulated 5-MTHF | 5-MTHF incorporated into granules or agglomerates to improve powder flow and handling. | Tablet manufacture, sachets, stick packs, and large-scale dry blending. | Better flow, reduced dust, and easier feeding compared with some fine powders. | Confirm active loading, granule-size range, friability, disintegration impact, carrier composition, and homogeneity. | Protect from humidity and compression; validate transfer and hopper-feeding conditions. | High-throughput manufacturers needing improved processing performance. |
| 7 | Microencapsulated 5-MTHF | 5-MTHF enclosed within a protective coating or matrix to reduce exposure to oxygen, light, moisture, or incompatible ingredients. | Fortified foods, beverage powders, premixes, chewables, and multi-ingredient formulations. | Can improve handling and compatibility; release behavior depends on the coating system and process conditions. | Request coating composition, active loading, release profile, particle size, heat tolerance, processing compatibility, and allergen status. | Store in moisture-barrier packaging; avoid temperatures that may soften or damage the coating. | Buyers needing enhanced protection during blending, storage, or food processing. |
| 8 | 5-MTHF Premix | 5-MTHF diluted with a carrier such as a carbohydrate or another approved excipient to create a controlled-use premix. | Multivitamin blends, food fortification, animal nutrition where permitted, and automated dosing systems. | Improves dosing accuracy and reduces segregation risk for very low inclusion rates. | Verify active concentration, carrier identity, blend uniformity, particle-size matching, overage policy, and segregation testing. | Use uniform, moisture-resistant packaging and minimize repeated opening during production. | Industrial buyers dosing small quantities into large production batches. |
| 9 | Water-Dispersible 5-MTHF | Formulated or processed to disperse more readily in aqueous systems; may include a carrier or stabilizing matrix. | Liquid supplements, drink powders, oral nutrition products, and water-based premixes. | Improved dispersion compared with untreated hydrophobic or poorly wetting powders. | Check dispersion time, sedimentation, pH tolerance, light stability, preservative compatibility, and active recovery after processing. | Protect from humidity and heat; validate reconstitution conditions and container-closure performance. | Buyers developing liquid or reconstituted products. |
| 10 | Ready-to-Use 5-MTHF Dosage Forms | Finished capsules, tablets, powders, liquid drops, or sachets containing a declared amount of 5-MTHF. | Private-label supplements, clinical nutrition, e-commerce products, and market-specific consumer products. | Shortens formulation and filling work while providing a finished presentation for the target market. | Confirm dosage per serving, elemental or active folate declaration, excipients, stability period, label compliance, testing, and market authorization. | Follow finished-product storage conditions; verify blister, bottle, or sachet barrier performance. | Buyers prioritizing speed to market and lower in-house manufacturing complexity. |
